Reply to "The Dual personality of iron chelators: growth inhibitors or promoters?".
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منابع مشابه
The dual personality of iron chelators: growth inhibitors or promoters?
Iron is an essential nutrient for almost all living cells, and pathogenic bacteria are faced with severe iron limitation in the mammalian host (1). To make iron available during infection, most microorganisms produce and transport into the cell specific iron chelators (siderophores) or acquire iron bound to exogenous iron carriers, like xenosiderophores, heme, or the host’s transferrins (2). Du...
متن کاملHydrophilic Phytochelators in Iron Overload Condition
Background: Iron overload can cause many complications and damage many organs as well as physiologic functions. Consumption of phetochemicals and flavonoids with iron chelating ability, instead of synthetic iron chelators, can be less harmful and more effective. The aim of this review is to investigate hydrophilic phytochelators in iron overload condition. Methods: In this review, the possible ...
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Objective: The aim is to Identification of Promoters and Inhibitors Iranian University and to know the structural and contextual reasons for its realization or non-realization in the historical periods of "Qajar", "Pahlavi (first and second)" and "Islamic Revolution”. Methodology: In terms of research tradition, this research is qualitative, and in terms of purpose, it is practical, and in term...
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Earlier studies have shown that transferrin-gallium inhibits cellular iron incorporation and blocks DNA synthesis by decreasing the activity of the iron-dependent M2 subunit of ribonucleotide reducÃ-ase.We ex amined the growth-inhibitory effects of gallium nitrate in combination with clinically relevant inhibitors of ribonucleotide reducÃ-asefludarabine (an Ml subunit inhibitor), and iron chela...
متن کاملThe Iron Chelator, Dp44mT, Effectively Inhibits Human Oral Squamous Cell Carcinoma Cell Growth in Vitro and in Vivo
Oral squamous cell carcinoma (OSCC) is a common malignancy with a growing worldwide incidence and prevalence. The N-myc downstream regulated gene (NDRG) family of NDRG1, 2, 3, and mammary serine protease inhibitor (Maspin) gene are well-known modulators in the neoplasia process. Current research has considered iron chelators as new anti-cancer agents; however, the anticancer activities of iron ...
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 57 5 شماره
صفحات -
تاریخ انتشار 2013